Allergy and Autoimmune Disease
Genetic profiling of Vietnamese atopic dermatitis patients
Nguyen Van Dinh (PI)
This study was conducted in a cohort of 300 patients with moderate-to-severe atopic dermatitis at Vinmec Times City International Hospital, with the objectives to: (1) characterize the spectrum of common allergens; (2) analyze genotype–phenotype correlations; and (3) evaluate the associations between the skin microbiome and gut microbiome with disease phenotypes in patients with atopic dermatitis.
Theraphytoabel Theraphyto Intensive-Cure Ointment in Atopic Dermatitis
Nguyen Thi Minh Nguyet (PI), Nguyen Van Dinh (Co-PI)
This study was conducted to evaluate the clinical effectiveness of Theraphytoabel Theraphyto Intensive-Cure Ointment in patients with mild-to-moderate atopic dermatitis at Vinmec Times City International Hospital, while also monitoring treatment-related adverse events, and documenting patient satisfaction over three consecutive months of use. This project was funded by Chungnam National University and CARBOEXPERT (Korea).
Acarizax SLIT for house dust mite allergic rhinitis
Nguyen Van Dinh (PI), Nguyen Thi Minh Nguyet (Co-PI)
This is the first study to be conducted in Vietnam to evaluate the effectiveness of allergen immunotherapy, also known as allergen desensitization (AIT), using the sublingual immunotherapy (SLIT) tablet Acarizax in patients with house dust mite–induced allergic rhinitis, with or without concomitant asthma. The study also evaluates the correlation between changes in the biomarker FeNO and treatment response, and investigates underlying mechanisms through pharmacogenomic and immunologic evaluations performed before and after treatment.
Clinical characteristics and genetic variations in hereditary angioedema in Vietnam
Nguyen Van Dinh (PI)
This study was conducted to: (1) describe the clinical and laboratory characteristics of patients with hereditary angioedema (HAE) in the Vietnamese population; (2) identify and analyze genetic variants associated with HAE; and (3) investigate genotype–phenotype correlations in patients with HAE. The study has been underway at the Center of Allergy and Clinical Immunology, Vinmec Times City International Hospital since January 2024.
Gene signatures in drug hypersensitivity in Vietnamese
Nguyen Van Dinh (PI)
The study aims to evaluate the association between genetic characteristics and drug hypersensitivity reactions, with the following objectives:
(1) To screen for high-risk HLA alleles in order to prevent severe cutaneous adverse reactions (SCARs) induced by carbamazepine (CBZ) and allopurinol.
(2) To comprehensively identify genetic susceptibility markers to more accurately predict CBZ- and allopurinol-associated SCARs, thereby developing an integrated allergy risk assessment model based on whole-exome sequencing (WES) analyses comparing the drug-allergic patient group with a drug-tolerant control group.
(3) To explore genetic signatures of hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) in Vietnamese individuals using a case–control study design leveraging whole-genome sequencing (WGS) data and genotyping microarrays.
The study was conducted at Vinmec Times City International Hospital, the National Children’s Hospital, and Bach Mai Hospital, with funding from the VinBigData, from September 2020 to October 2023.
VinAllergy – Allergy Management Software
Nguyen Van Dinh (PI)
The VinAllergy project proposes the development of a “two-way” digital health solution comprising a mobile application for patients and a web-based platform for healthcare professionals. The system will enable users to log exposures/allergens, monitor symptoms, and receive timely reminders and alerts, while supporting clinicians with standardized tools for documenting allergy histories, assessing risk, and managing records. A key feature is the integration of predictive models that use longitudinal health data, environmental factors, and geographic context to identify high-risk individuals and forecast seasonal or location-specific surges. Through proactive monitoring, early warning alerts, and clinically validated action plans, VinAllergy aims to reduce severe flare-ups and emergency visits, improve treatment adherence, and contribute to a sustainable, evidence-based approach to allergy management in Vietnam.