Biography
Dr. Thanh earned his Ph.D. in Biomedical Engineering from Tufts University, focusing his research on bioinformatics, cancer neuroscience, and tissue engineering.
Before joining VinUniversity, Dr. Le worked as a Clinical Research Specialist at the Hi-Tech Center of Vinmec International Hospital in Hanoi, Vietnam. His research experience includes exploring microbiome signatures for colorectal cancer, developing innovative heart-on-a-chip models from patient-specific induced pluripotent stem cells, and applying multi-omics approaches to identify novel Vietnamese tumor biomarkers.
Dr. Le’s research contributions have significantly advanced the understanding of cancer biology and microbiome, evidenced by publications in journals including Gut Microbes, Frontiers in Oncology, Breast Cancer Research, and NPJ Breast Cancer. At VinUniversity, Dr. Le will actively contribute to interdisciplinary research collaborations, curriculum development and mentorship, reflecting his dedication to scientific advancement, educational excellence.
Microbiome, Tissue Engineering, Bioinformatics, Multi-omics
1. Le, Thanh Thien, Tram Ngoc Hoang, Dylan Huy Do, Xuan-Hung Nguyen, Cynthia Huynh, Hang Dao Viet, Vu Quoc Dat et al. “”Current state of microbiota clinical applications in neonatal and pediatric bacterial infections.”” Gut Microbes 17, no. 1 (2025): 2529400.
2. Nguyen, Chien Ngoc, Trang Thi Nhu Nguyen, Thanh Thien Le, Phuong Bich Vu, Lan Thi Phuong Le, Nha Ba Pham, Huong Minh To et al. “”Effectiveness, safety, and practicality of intramuscular progesterone in restoring pregnancy outcomes during frozen embryo transfers.”” Frontiers in Endocrinology 16 (2025): 1592956.
3. Le, Thanh Thien, Tung S. Ha, Linh M. To, Quang M. Dang, Hoa T. Bui, Thanh D. Tran, Phuong T. Vu, Hoan B. Giang, Dung T. Tran, and Nguyen X. Hung. “Osteosarcoma patient with Li-Fraumeni syndrome: the first case report in Vietnam.” Frontiers in Oncology 14 (2024).
4. Conner, Sydney J., Justinne R. Guarin, Thanh T. Le, Jackson P. Fatherree, Charlotte Kelley, Samantha L. Payne, Savannah R. Parker et al. “”Cell morphology best predicts tumorigenicity and metastasis in vivo across multiple TNBC cell lines of different metastatic potential.”” Breast Cancer Research 26, no. 1 (2024): 43.
5. Tran, Bach Xuan, Duy Sy Dang, Trang Huyen Thi Dang, Thanh Thien Le, Thao Phuong Hoang, Laurent Boyer, Pascal Auquier et al. “”Assessing willingness to pay for children’s COVID-19 vaccination among healthcare providers and users using a theory-based discrete choice experiment.”” Scientific Reports 14, no. 1 (2024): 22352.
6. Nguyen, Long Bao, Linh Gia Vu, Thanh Thien Le, Xuan Thanh Nguyen, Nam Gia Dao, Duy Cao Nguyen, Trang Huyen Thi Dang et al. “”Impact of interventions on the quality of life of cancer patients: a systematic review and meta-analysis of longitudinal research.”” Health and Quality of Life Outcomes 21, no. 1 (2023): 112.
7. Le, Thanh T., and Madeleine J. Oudin. “”Understanding and modeling nerve–cancer interactions.”” Disease Models & Mechanisms 16.1 (2023): dmm049729.
8. Do, Xuan-Hai, Mai Thi Le, Thu Huyen Nguyen, Thanh Thien Le, Xuan-Hung Nguyen, Thanh Binh Mai, Thi My Nhung Hoang, and Uyen Thi Trang Than. “”Detection of sFas, sCD137, and IL-27 Cytokines as Potential Biomarkers for Hepatocellular Carcinoma Diagnosis.”” Journal of Hepatocellular Carcinoma (2023): 783-793.
9. Vu, Son Hai, Ha Hong Pham, Thao Thi Phuong Pham, Thanh Thien Le, Manh-Cuong Vo, Sung-Hoon Jung, Je-Jung Lee, and Xuan-Hung Nguyen. “”Adoptive NK cell therapy-a beacon of hope in multiple myeloma treatment.”” Frontiers in Oncology 13 (2023): 1275076.
10. Le, Thanh T., Samantha L. Payne, Maia N. Buckwald, Lily A. Hayes, Christopher B. Burge, and Madeleine Oudin. “”Sensory nerves enhance triple-negative breast cancer invasion and metastasis via the axon guidance molecule PlexinB3.”” Npj Breast Cancer 8, no. 1 (2022): 1-11.
11. Payne, Samantha L., Priyanka Ram, Deepti H. Srinivasan, Thanh T. Le, Michael Levin, and Madeleine J. Oudin. “”Potassium channel-driven bioelectric signaling regulates metastasis in triple-negative breast cancer.”” EBioMedicine 75 (2022): 103767.
12. Perreault, Luke R., Thanh T. Le, Madeleine J. Oudin, and Lauren D. Black 3rd. “”RNA sequencing indicates age-dependent shifts in the cardiac fibroblast transcriptome between fetal, neonatal, and adult developmental ages.”” Physiological Genomics 53, no. 10 (2021): 414-429.
Graduate Student Travel Fund, Tufts University 2021
Graduate Student Research Symposium, Tufts University – First Place 2020
Helmsley Scholarship, Cold Spring Harbor Laboratory 2018
Graduate Student Research Competition Award, Tufts University 2018
Undergraduate Research program grant (Fall), University of Minnesota 2016
Undergraduate Research program grant (Spring), University of Minnesota 2016
BME Undergraduate Research Seminar, University of Minnesota – First Place 2016